CBD & Your Endocannabinoid System

Journal Back to Archive09.29.20
Is CBD Legal?

YES, it is legal nationwide. In December 2018, the Farm Bill was approved. Passing legislation allowing the sale of products containing hemp-derived Cannabinoids (CBD, CBG, CBN, THC), as long as the concentration of THC within each product is no more than 0.3%. All Mello products are legal. *Curious about what the TSA does when you travel with CBD, read more here

What is CBD?

CBD pronounced CANNA – BIDDIE – YOL is a Cannabinoid found in the dried resin glands of the female Cannabis plant. It is only found in the stalks, stems, and flowers, never in the seeds. 

What are Cannabinoids?

Cannabinoids are naturally occurring compounds found in the cannabis plant. THC (tetrahydrocannabinol), CBD (cannabidiol), CBN (Cannabinol), CBC (Cannabichromene) and CBG (Cannabigerol) are all cannabinoids. At least 113 different cannabinoids have been isolated from the Cannabis plant, however, the most known and studied are THC and CBD.

Does Your Body Produce Cannabinoids?

YES. Your body actually needs them to operate and so produces its own endogenous cannabinoids —Endocannabinoids. Experts have identified two key endocannabinoids so far: anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These endocannabinoids are necessary for your body to function and so are produced on-demand when needed. 

Why Does Your Body Produce Endocannabinoids?

Endocannabinoids broadly work to stimulate or suppress the responses of your body’s receptors. The role of your receptors is to respond when they detect a negative change in your body’s brain, organs, connective tissues, glands, and immune cells and stimulate a healthy response —your receptor detects an injury, and so tells your cells to create extra white blood cells. They transmit information about changing conditions to the inside of the cell and kick-start the appropriate cellular response.

Often, The Body Doesn’t Produce Enough Endocannabinoids, and as a Result, Our Cells are Not Regulated and the Body Becomes Unbalanced, Allowing Diseases to Occur.

What is the Endocannabinoid System (ECS)?

Think of this as the term for the system of endocannabinoids and their receptors located throughout the body. So, the ECS is the body’s internal regulator, it is responsible for regulating and balancing many processes in the body, including immune response, communication between cells, appetite and metabolism, memory, nervous system, and more.

What is Endocannabinoid Deficiency?

This is a theory that suggests that low endocannabinoid levels in the body may explain why some conditions develop. Our body only produces endocannabinoids on demand and does not keep a store for when needed. So if you have, or are recovering from a chronic injury or illness, or have a genetic disposition to produce fewer endocannabinoids. Your body may never actually produce enough endocannabinoids for you to lead a healthy life. Dr. Ethan Russo first proposed the theory and suggested that supplementing the body with cannabinoids found in cannabis was proving effective at alleviating this deficiency.

To Increase Your Body’s Endocannabinoids Take A Daily Dose of CBD

Or, you could eat a balanced diet, get a lot of sleep, reduce your stress, decrease your intake of alcohol, and exercise regularly —but is that regiment even possible? We all live normal but at times very unrestrained lives and so the most convenient way for you to keep your Endocannabinoid System in check is to take a daily dose of CBD.

What Is Anandamide?

Anandamide plays a role in the generation of our positive reward response, and so motivates us to continue repeating a pleasurable behavior. Basically keeps rewarding us to be happy. It is otherwise known as the “Bliss Molecule” and has been proven to be responsible for the intense beneficial effects of exercise —AKA Runner’s High.

What is 2-arachidonoylglycerol (2-AG)?

2-AG helps referee the immune responses within the body. It actually travels backward along the messenger pathway to tell the body to stop sending so many attack cells to an affected area. And, in doing so can help reduce inflammation, and encourage a normal immune response.

What is THC?

Tetrahydrocannabinol (THC) is an equally known cannabinoid because it accounts for the highest concentration in the Cannabis plant, and also gets you ‘HIGH’. THC is a Schedule I controlled substance and so federally illegal. You can access THC if you live in a state where it is recreationally legal or a registered Medical Marijuana Patient. Studies have found that THC can reduce nausea and vomiting, increase appetite, provide pain relief, and improve sleep.

What is CBN?

Cannabinol (CBN) is actually THC that has been exposed to heat and light for too long. It is a fairly under-researched cannabinoid, and so we are hesitant to call out any major health benefits. But potentially —could serve as an effective sleep aid.

What is CBG?

Cannabigerol (CBG) is the chemical parent of THC and CBD, meaning that CBG turns into other cannabinoids as the plant matures. There are preliminary studies indicating CBG might be successful in slowing the growth of cancer cells, but it is yet to be demonstrated in a way the health community accepts. It is very expensive as you need many plants to produce a standard dose —it is the chemical parent so there is little to none left by the time the plant has matured. 

What is CBC?

Cannabichromene (CBC) is the third most concentrated cannabinoid in the plant after THC and CBD. It was recently discovered that CBC is very effective against inflammation —it operates differently to non-steroidal anti-inflammatory drugs, in that it actually reduces edema (swelling) rather than masking it, taking the swelling away does encourage the body to heal itself.