CBD Suppositories for Endometriosis: Clinical Trials Show Long Term Results

A recent study showed that Cannabinoids can improve endometriosis symptoms in mice. It showed that those mice who had endo experienced anxiety and pain which affected their cognitive function. But when given cannabinoids their cognitive function improved, drawing the hypothesis that their anxiety and pain from the endo was the cause of their brain fog. 

It is also widely accepted that endometrial cells behave in the same way as cancer cells, BUT BENIGN. So when referencing other studies that prove phtyo-cannabinoids could help endometriosis we can reference cancer + Cannabis studies. This study shows cannabinoids stop tumor cells from growing in mice. Mice given cannabinoids were able to destroy alien cells in their bodies. Endometrial cells growing outside your uterus are ‘alien’ cells. Potentially if you feed an endo patient the phytocannabinoid CBD their body will begin to destroy these alien cells. This has also been proven here and here.

Often the collection of endo cells can develop a very rich population of nerve endings, causing serious pain. Studies have shown that endocannabinoids help regulate nerve growth and their receptors —CBD can desensitize our nerves, by preventing the nerve receptors from being turned on, so we do not get the message to our brain about the pain. More here and here.

When you have endo your body is confused and can start to attack all the cells in your body, as it does not know what to do with the dead cells. Studies show your ECS can prevent the body’s inflammatory response when stimulated with additional Phytocannabinoids, like CBD. Another study shows how CBD can also reduce the body’s T-cells proliferation, and is a promising treatment of auto-immune disease.

*ECS – Endocannabinoid system – A system of receptors (CB1 and CB2) that regulate the balance in our CNS and PNS, inflammation, immune system, and hormones.

The most promising study shows that modulation of the ECS through therapeutic doses of cannabinoids could be the key to real endometriosis treatment. This study shows a link between the systems maintained by the ECS and our body’s endometrial cells. And draws the conclusion that if we regulate our ECS we could actually treat and maybe cure endometriosis. A second study out of the UK studied the link between our *ECS and endometriosis. The research showed that women without endometriosis had well functioning CB1 and CB2 receptors. But, women with endometriosis had very sluggish ones. Our ECS system needs cannabinoids to keep it functioning effectively. Thus, perhaps daily cannabinoids could help women with endometriosis combat the disorder.

Endometriosis, also known as 'endo', is a condition that occurs when endometrial cells grow outside of the uterus. These cells are healthy if they remain inside the uterus and are shed during menstruation. However, when they grow in other parts of the body, such as the vagina, bowel, bladder, or rectum, they can cause severe pain and discomfort. This condition can become quite serious, particularly when these cells implant and grow on the ovaries, fallopian tubes, and intestines. The tissue behaves in the same way as "healthy" period cells each month by growing, thickening, and breaking down. But as these cells have nowhere to go, over time, the cells die and become dead tissue trapped and inflamed within these areas.

This condition is more common than many people realize, affecting 11% of individuals assigned female at birth in the US.

Symptoms of endometriosis vary, the obvious ones are severe pelvic pain, painful periods, pain during sex, fatigue, diarrhea or constipation, and infertility. However, some women may also experience headaches, brain fog, or mood and appetite changes. We list the common ones below:

Pelvic Pain: Chronic pelvic pain, often worsening during menstruation or intercourse, is a hallmark symptom of endometriosis.

Menstrual Irregularities: Very Painful Periods, Heavy almost hemorrhage type bleeding, and large visible clots. 

Painful Sex: Vulva or Vaginal pain, cervical or pelvic tension, and deep lower back ache during intercourse. A painful orgasm can also be experienced. 

Infertility: Endometriosis can make it harder to get pregnant because it changes the way the reproductive organs work. It can cause problems like swelling, scarring, and hormone changes that make it difficult for pregnancy to happen.

No one knows yet. But we list a few of the longest-held reasons widely accepted by most doctors:

Retrograde Menstrual Flow: This is when Menstrual blood accidentally flows the wrong way. Some doctors believe that a cause of endometriosis is when some of your menstrual blood (containing endometrial cells) flows the wrong way and heads out of your fallopian tubes to other parts of your body. However, it is worthwhile to note that there is zero evidence to support this claim. 

Hormonal Imbalance: When your estrogen is out of balance with your progesterone levels, this imbalance may promote the growth of endometrial tissue outside the uterus.

Genetics: Generally speaking, individuals with the condition often have a close relative who also experiences menstruation-related issues.

Challenged or Overworked Immune System: A faulty immune system, may fail to recognize the alien cells and thus neglect to destroy and remove them. 

And more lately, due to promising research and evidence, doctors are acknowledging that our Endocannabinoid System may play a large role in endometriosis. Research has shown that an imbalanced ECS could actually cause endometriosis flare-ups. This study shows that ECS modulation through therapeutic doses of topical CBD could be a potential cure to combat endometriosis.

At present, endometriosis does not have a cure. Doctors treat the symptoms of endometriosis with medication, rather than trying to isolate and cure this condition. Below we list possible treatments. However these can be very invasive procedures, and often need to be repeated, as the cells do come back.

• Anti-inflammatories
• Hormonal contraception
• Gonadotropin-releasing hormone, which can regulate estrogen and progesterone production. 
• Laparoscopic excision surgery, to scrape or remove dead cells. 
• Hysterectomy (removal of the uterus)

We strongly believe that therapeutic doses of topical CBD can be a potential treatment for endometriosis. In particular regular usage of CBD Suppositories, before your bleed and during. If we regulate the ECS we could stop endometriosis flare-ups, and decrease the pain and inflammation associated with endometriosis. We recommend taking Mello Flo, a rectal or vaginal suppository that packs 75MG of CBD. We recommend taking this three days before your expected flow.

As per the studies listed above, taking CBD Suppositories regularly may offer potential therapeutic benefits for managing endometriosis symptoms. Emerging research suggests that CBD:

1. May alleviate the brain fog associated with Endometriosis
2. Could help the body destroy the ‘alien' endometrial cells and prevent them from spreading
3. Is an effective endometriosis pain reliever
4. May combat the auto-immune issues you can get from Endometriosis by decreasing inflammation
5. May help The ECS regulate the cells and systems responsible for endometriosis, and regulating this could be key to treating the condition

We chose CBD suppositories, as a delivery method specifically, as it will be absorbed immediately and directly soothe the vagina, pelvic organs, and abdomen. Offering an instant relief for localized symptoms.