CBD for Endometriosis Relief: Clinical Trials Show Effective Treatment

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What does the latest clinical research say about the effectiveness of CBD as a relief for endometriosis?

CBD shows promise as a potential treatment for endometriosis, with the ability to alleviate pain, decrease inflammation, destroy the alien endometrial cells and prevent them from multiplying, and prevent an autoimmune response. Studies Cited Below


Of particular interest is a double-blind study on women with deep endometriosis, this study is aiming to further explore the potential benefits of cannabinoids in endometriosis treatment. The study is in progress and results will be published soon. 


Anecdotally, our customers with endometriosis have found relief using Mello Flo, our CBD suppositories designed to reduce lower body inflammation, relax uterine cramping, relieve pelvic and lower back pain, and restore whole hormone health.


While there is a growing body of evidence, and ongoing clinical trials that support the effectiveness of cannabinoids, conclusive evidence for an endometriosis cure has not yet been established.

CBD can alleviate the brain fog associated with Endometriosis

A recent study showed that Cannabinoids can improve endometriosis symptoms in mice. It showed that those mice who had endo experienced anxiety and pain which affected their cognitive function. But when given cannabinoids their cognitive function improved, drawing the hypothesis that their anxiety and pain from the endo was the cause of their brain fog. 

CBD could help the body destroy the ‘alien' endometrial cells and prevent them from spreading

It is also widely accepted that endometrial cells behave in the same way as cancer cells, BUT BENIGN. So when referencing other studies that prove phtyo-cannabinoids could help endometriosis we can reference cancer + Cannabis studies. This study shows cannabinoids stop tumor cells from growing in mice. Mice given cannabinoids were able to destroy alien cells in their bodies. Endometrial cells growing outside your uterus are ‘alien’ cells. Potentially if you feed an endo patient the phytocannabinoid CBD their body will begin to destroy these alien cells. This has also been proven here and here.

CBD is an effective endometriosis pain reliever

Often the collection of endo cells can develop a very rich population of nerve endings, causing serious pain. Studies have shown that endocannabinoids help regulate nerve growth and their receptors —CBD can desensitize our nerves, by preventing the nerve receptors from being turned on, so we do not get the message to our brain about the pain. More here and here.

CBD can combat the auto-immune issues you can get from Endometriosis by decreasing inflammation

When you have endo your body is confused and can start to attack all the cells in your body, as it does not know what to do with the dead cells. Studies show your ECS can prevent the body’s inflammatory response when stimulated with additional Phytocannabinoids, like CBD. Another study shows how CBD can also reduce the body’s T-cells proliferation, and is a promising treatment of auto-immune disease.

Our ECS maintains the cells and systems responsible for endometriosis, and regulating it could be key to treating the condition

*ECS – Endocannabinoid system – A system of receptors (CB1 and CB2) that regulate the balance in our CNS and PNS, inflammation, immune system, and hormones.


The most promising study shows that modulation of the ECS through therapeutic doses of cannabinoids could be the key to real endometriosis treatment. This study shows a link between the systems maintained by the ECS and our body’s endometrial cells. And draws the conclusion that if we regulate our ECS we could actually treat and maybe cure endometriosis. A second study out of the UK studied the link between our *ECS and endometriosis. The research showed that women without endometriosis had well functioning CB1 and CB2 receptors. But, women with endometriosis had very sluggish ones. Our ECS system needs cannabinoids to keep it functioning effectively. Thus, perhaps daily cannabinoids could help women with endometriosis combat the disorder.

What is Endometriosis?

Endometriosis, also known as 'endo', is a condition that occurs when endometrial cells grow outside of the uterus. These cells are healthy if they remain inside the uterus and are shed during menstruation. However, when they grow in other parts of the body, such as the vagina, bowel, bladder, or rectum, they can cause severe pain and discomfort. The tissue behaves in the same way as healthy 'period cells' each month by growing, thickening, and breaking down. Over time, the dead tissue becomes trapped and inflamed. 


This condition is more common than many people realize, affecting 11% of individuals assigned female at birth in the US.

Endometriosis Treatment

At present, endometriosis does not have a cure. Doctors treat the symptoms of endometriosis with medication and sometimes recommend surgery to remove the dead tissue, which is a very invasive procedure and may need to be repeated.


We do strongly believe that therapeutic doses of topical CBD can be a potential treatment for endometriosis. If we regulate the ECS we could stop endometriosis flare-ups, and decrease the pain and inflammation associated with endometriosis. We recommend taking Mello Flo, a rectal or vaginal suppository that packs 75MG of CBD. We recommend taking this three days before your expected flow.

What are the Symptoms of Endometriosis?

Symptoms of endometriosis include severe pelvic pain, painful periods, pain during sex, fatigue, diarrhea or constipation, and infertility. Some women may also experience heavy periods, bleeding or spotting between periods, and digestive issues.

Endometriosis Causes

No one knows yet. But the most popular and longest-held is that Menstrual blood accidentally flows the wrong way. This seems whacky but it is widely accepted and is termed ‘Retrograde Menstrual Flow’. Doctors believe that the main cause of endometriosis is when some of your menstrual blood (containing endometrial cells) flows the wrong way and heads out your fallopian tubes to other parts of your body. 


Lately, more doctors are beginning to believe that our Endocannabinoid System may play a large role in endometriosis. And could actually cause endometriosis flare-ups when not operating effectively. This study shows that ECS modulation through therapeutic doses of topical CBD could be a potential cure to combat endometriosis. 

Other potential causes of endometriosis: